Prognostic significance of hypoxia-inducible factor- 1a, TWIST1 and Snail expression in resectable non- small cell lung cancer
نویسندگان
چکیده
1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; 2 Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan; 3 School of Medicine, National Yang-Ming University, Taipei, Taiwan; 4 Department of Surgery, Cathay General Hospital and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan; 5 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan; 6 Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; 7 Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 8 Genomic Research Center, Taipei Veterans General Hospital, Taipei, Taiwan
منابع مشابه
Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer.
BACKGROUND Metastasis is the most common cause of disease failure and mortality for non-small cell lung cancer (NSCLC) after surgical resection. Snail and TWIST1 are epithelial-mesenchymal transition (EMT) regulators which induce metastasis. Intratumoral hypoxia followed by stabilisation of hypoxia-inducible factor 1alpha (HIF-1alpha) promotes metastasis through regulation of certain EMT regula...
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